Project
Integrated innovative artificial intelligence, genomic, and biomedical technologies in healthcare: Objective diagnosis, personalized therapy, and determining the etiology of major mental disorders
Funding: RGC Strategic Topic Grant (STG), HKD $37.236M
Objectives: Develop innovative AI and genomic technologies for objective diagnosis and personalized treatment of major psychiatric disorders, including major depressive disorder, schizophrenia and bipolar disorder.
Project
Unravelling the black box between air pollution and public health for transformative air quality management
Funding: RGC Theme-based Research Scheme (TRS), HKD $41.4M
Objectives:
- Develop integrated approaches that address the global puzzle of what components drive PM2.5 health effects in different regions.
- Generate solid evidence of key PM2.5 toxic components and emission sources to specific index diseases as a foundation for making public policies.
Project
Understanding the molecular mechanism linking mRNA decay and capping with post-transcriptional gene silencing
Funding: NSFC/RGC Collaborative Research Scheme (NSFC/RGC CRS), HKD $3.6M + RMB 3M
Objectives:
- Determine if and how the translation process leads to ct-siRNA generation.
- Determine the effects of the defects in mRNA capping on siRNA generation and its interconnection with the translational process.
- Reveal biological functions and mechanisms linking ct-siRNA biogenesis and PTGS of genes with plant stress responses.
Project
Subtyping and diagnosis of schizophrenia by systems-biology analytics
Funding: Health and Medical Research Fund (HMRF), HKD $1.420M
Objectives: Define objective subtypes of schizophrenia using systems-biology analytics and develop personalized therapy for schizophrenia treatment.
Project
High-resolution single-cell multi-omics: Joint profiling of multiple types of biomolecules in the same single cell
Funding: RGC Collaborative Research Fund (CRF), HKD $6.412M
Objectives: Develop an innovative technology for profiling DNA, RNA and proteins in the same single cell at the same time; apply the new technology to cancer research.
